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Granja et al. GSE139369 mixed-phenotype acute leukemia for Besca

Name: Granja et al. GSE139369 mixed-phenotype acute leukemia for Besca
Keywords: 3. Good health

Research datakeyboard_double_arrow_right Dataset 07 Jul 2020 English Publisher:Zenodo

Authors: Schwalie, Petra; Sonrel Anthony;

doi: 10.5281/zenodo.3933885 , 10.5281/zenodo.4419527

Granja et al. GSE139369 mixed-phenotype acute leukemia for Besca

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Abstract

The gene expression matrices were downloaded from GEO (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE139369), originally published by Granja JM, Klemm S, McGinnis LM, Kathiria AS et al. Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia. Nat Biotechnol 2019 Dec;37(12):1458-1465. PMID: 31792411. Individual raw matrices were merged to be uploaded directly with Besca. We then reprocessed the dataset using the Besca package (https://github.com/bedapub/besca). Raw processed h5ad is available. Processed and annotated h5ad was annotated using the notebook available at https://github.com/bedapub/besca_publication_results/tree/master/hematopoietic/Granja2019 Citeseq data raw data is available under Granja2019_adt_raw.h5ad. The results of CLR/DSB normalization with it associated clustering and UMAP were added to the annotated h5ad file.

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