Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Copyright policy )Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.
- Massachusetts Institute of Technology United States
- University of Pittsburgh United States
- University of Liège Belgium
- Ghent University Hospital Belgium
- University of Cambridge United Kingdom
Genetic-variation, /dk/atira/pure/subjectarea/asjc/1300/1311, Cells, Quantitative Trait Loci, 610, Expression, Genetics & genetic processes, Sciences de la santé humaine, Génétique & processus génétiques, Crohn Disease, Nonsynonymous SNPS, Genetics, Humans, Genetic Predisposition to Disease, Human health sciences, risk, Crohn Disease/genetics, Genome, Human, Variants, 1103 Clinical Sciences, Gastroentérologie & hépatologie, Colitis, Life sciences, IL-23 gene–deficient mice, Sciences du vivant, Multiple, Gastroenterology & hepatology
Genetic-variation, /dk/atira/pure/subjectarea/asjc/1300/1311, Cells, Quantitative Trait Loci, 610, Expression, Genetics & genetic processes, Sciences de la santé humaine, Génétique & processus génétiques, Crohn Disease, Nonsynonymous SNPS, Genetics, Humans, Genetic Predisposition to Disease, Human health sciences, risk, Crohn Disease/genetics, Genome, Human, Variants, 1103 Clinical Sciences, Gastroentérologie & hépatologie, Colitis, Life sciences, IL-23 gene–deficient mice, Sciences du vivant, Multiple, Gastroenterology & hepatology
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).2K popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 0.1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.01%
Citations provided by BIP!Popularity provided by BIP!