Activation-dependent internalization of the human prostacyclin receptor
Copyright policy )Activation-dependent internalization of the human prostacyclin receptor
Prostacyclin (PGI2), the major cyclooxygenase-derived arachidonic acid metabolite formed in macrovascular endothelial cells’, is a potent vasodilator, an inhibitor of platelet aggregation2 and smooth muscle proliferation3 in vitro and an antithrombotic in mice4. Given the absence of PGI2 antagonists its role in the prevention of vascular disease in vivo has remained speculative.
- University of Pennsylvania United States
Inositol Phosphates, Recombinant Fusion Proteins, Receptors, Prostaglandin, Receptors, Epoprostenol, Transfection, Epoprostenol, Polymerase Chain Reaction, Cell Line, Kinetics, Protein Transport, Cyclic AMP, Humans, Iloprost, Platelet Aggregation Inhibitors
Inositol Phosphates, Recombinant Fusion Proteins, Receptors, Prostaglandin, Receptors, Epoprostenol, Transfection, Epoprostenol, Polymerase Chain Reaction, Cell Line, Kinetics, Protein Transport, Cyclic AMP, Humans, Iloprost, Platelet Aggregation Inhibitors
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