YAC/BAC-Based Physical and Transcript Mapping around the Gracile Axonal Dystrophy (gad) Locus Identifies Uchl1, Pmx2b, Atp3a2, and Hip2 Genes
Copyright policy )YAC/BAC-Based Physical and Transcript Mapping around the Gracile Axonal Dystrophy (gad) Locus Identifies Uchl1, Pmx2b, Atp3a2, and Hip2 Genes
We generated a yeast artificial chromosome (YAC)/bacterial artificial chromosome (BAC)-based physical and transcript map of a region containing the gracile axonal dystrophy (gad) locus on mouse chromosome 5. The YAC/BAC contig consists of 13 YAC and 49 BAC clones onto which 4 genes, 40 expressed sequence tags, and 7 new DNA polymorphisms were ordered. Using this physical map, we mapped Uchl1 encoding ubiquitin carboxyl-terminal hydrolase I, whose deletion has been determined to cause the gad mutation. We also mapped three other recently identified genes: Hip2, encoding Huntingtin interacting protein 2; Atp3a2, encoding a P-type ATPase; and Pmx2b, encoding PHOX2b.
- RIKEN Japan
- National Center of Neurology and Psychiatry Japan
- Kindai University Japan
Adenosine Triphosphatases, Expressed Sequence Tags, Genetic Markers, Homeodomain Proteins, Molecular Sequence Data, Neuroaxonal Dystrophies, Membrane Proteins, Mice, Inbred Strains, Exons, Chromosomes, Bacterial, Physical Chromosome Mapping, Ligases, Chromosome Walking, Contig Mapping, Mice, Animals, Humans, Phospholipid Transfer Proteins, Carrier Proteins, Chromosomes, Artificial, Yeast
Adenosine Triphosphatases, Expressed Sequence Tags, Genetic Markers, Homeodomain Proteins, Molecular Sequence Data, Neuroaxonal Dystrophies, Membrane Proteins, Mice, Inbred Strains, Exons, Chromosomes, Bacterial, Physical Chromosome Mapping, Ligases, Chromosome Walking, Contig Mapping, Mice, Animals, Humans, Phospholipid Transfer Proteins, Carrier Proteins, Chromosomes, Artificial, Yeast
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