RanBPM is a novel binding protein for p75NTR
Copyright policy )RanBPM is a novel binding protein for p75NTR
The neurotrophin receptor p75NTR can induce signal transduction both in vivo and in vitro. The mechanisms by which p75NTR transduces signals have remained mostly unknown. Using yeast two-hybrid system, we identified the Ran-binding protein (RanBPM) as an interactor with the intracytoplasmic domain of p75NTR (p75ICD). The interaction was then validated by immunoprecipitation in mammalian cells and immunoblotting analysis. The domain in p75ICD interacting with RanBPM was mapped to the death domain.
- Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. China (People's Republic of)
- PEKING UNION MEDICAL COLLEGE China (People's Republic of)
- Chinese Academy of Medical Sciences & Peking Union Medical College China (People's Republic of)
Binding Sites, Molecular Sequence Data, Nuclear Proteins, Receptor, Nerve Growth Factor, Protein Structure, Tertiary, Cytoskeletal Proteins, Mice, ran GTP-Binding Protein, Two-Hybrid System Techniques, COS Cells, Animals, Amino Acid Sequence, Sequence Alignment, Adaptor Proteins, Signal Transducing
Binding Sites, Molecular Sequence Data, Nuclear Proteins, Receptor, Nerve Growth Factor, Protein Structure, Tertiary, Cytoskeletal Proteins, Mice, ran GTP-Binding Protein, Two-Hybrid System Techniques, COS Cells, Animals, Amino Acid Sequence, Sequence Alignment, Adaptor Proteins, Signal Transducing
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