Regulated Intramembrane Proteolysis Takes Another Twist
Copyright policy )Regulated Intramembrane Proteolysis Takes Another Twist
Rhomboid, a seven-transmembrane domain protein, has been shown genetically to potentiate EGFR signaling via the TGFalpha-like ligand Spitz. Here we discuss recently published papers that identify Rhomboid as a novel serine protease, cleaving Spitz within its transmembrane domain.
- University of Mary United States
- Washington University in St. Louis United States
Epidermal Growth Factor, Cell Membrane, Serine Endopeptidases, Golgi Apparatus, Membrane Proteins, Protein Structure, Tertiary, Animals, Drosophila Proteins, Humans, Drosophila, Protein Processing, Post-Translational, Developmental Biology
Epidermal Growth Factor, Cell Membrane, Serine Endopeptidases, Golgi Apparatus, Membrane Proteins, Protein Structure, Tertiary, Animals, Drosophila Proteins, Humans, Drosophila, Protein Processing, Post-Translational, Developmental Biology
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