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Infection and Immunity
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Infection and Immunity
Article . 1993 . Peer-reviewed
License: ASM Journals Non-Commercial TDM
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Infection and Immunity
Article . 1993
Data sources: Europe PubMed Central
https://dx.doi.org/10.1128/iai...
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Molecular genetic analysis of beta-toxin of Clostridium perfringens reveals sequence homology with alpha-toxin, gamma-toxin, and leukocidin of Staphylococcus aureus

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1993 English Publisher:American Society for MicrobiologyJournal:Infection and Immunity, volume 61, pages 3,958-3,965 (issn: 0019-9567, eissn: 1098-5522, Copyright policy )
Authors: S E, Hunter; J E, Brown; P C, Oyston; J, Sakurai; R W, Titball;

doi: 10.1128/iai.61.9.3958-3965.1993

pmid: 8359918

pmc: PMC281100

Molecular genetic analysis of beta-toxin of Clostridium perfringens reveals sequence homology with alpha-toxin, gamma-toxin, and leukocidin of Staphylococcus aureus

Abstract

Oligonucleotide probes designed on the basis of the N-terminal sequence of Clostridium perfringens beta-toxin were used to isolate the encoding gene (cpb). The nucleotide sequence of cpb was determined, and on the basis of DNA hybridization experiments it was shown that the gene is found only in type B and C strains of C. perfringens. The deduced amino acid sequence of the beta-toxin revealed homology with the alpha-toxin, gamma-toxin, and leukocidin of Staphylococcus aureus. The beta-toxin purified from C. perfringens appeared to exist in monomeric and multimeric forms. Recombinant beta-toxin, produced in Escherichia coli, appeared to be mainly in the multimeric form.

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Keywords

Staphylococcus aureus, Base Sequence, Sequence Homology, Amino Acid, Clostridium perfringens, Bacterial Toxins, Molecular Sequence Data, Hemolysin Proteins, Open Reading Frames, Bacterial Proteins, Leukocidins, Escherichia coli, Amino Acid Sequence, Cloning, Molecular, Oligonucleotide Probes

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
126
Top 10%
Top 1%
Top 10%
gold
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