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International Journal for Parasitology
Article . 2003 . Peer-reviewed
License: Elsevier TDM
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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Article . 2003
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International Journal for Parasitology
Article . 2003
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/s00...
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Effects of KHEYLRFamide and KNEFIRFamide on cyclic adenosine monophosphate levels in Ascaris suum somatic muscle

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2003 United Kingdom English Publisher:Elsevier BVJournal:International Journal for Parasitology, volume 33, pages 199-208 (issn: 0020-7519, Copyright policy )
Authors: Marks, Nicola; Geary, T.G.; Thompson, D.P.; Davis, J.P.; Coscarelli, E.M.; Zinser, E.W.; Bowman, J.W.; +2 Authors

doi: 10.1016/s0020-7519(02)00259-x

pmid: 12633657

Effects of KHEYLRFamide and KNEFIRFamide on cyclic adenosine monophosphate levels in Ascaris suum somatic muscle

Abstract

KHEYLRF-NH(2) (AF2) is a FMRFamide-related peptide (FaRP) present in parasitic and free-living nematodes. At concentrations as low as 10 pM, AF2 induces a biphasic tension response, consisting of a transient relaxation followed by profound excitation, in neuromuscular strips prepared from Ascaris suum. In the present study, the effects of AF2 on cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP) and inositol-1,4,5-triphosphate (IP(3)) levels were measured following muscle tension recordings from 2 cm neuromuscular strips prepared from adult A. suum. AF2 induced a concentration- and time-dependent increase in cAMP, beginning at 1 nM; cAMP levels increased by 84-fold following 1 h exposure to 1 microM AF2. cGMP and IP(3) levels were unaffected by AF2 at concentrations

Country
United Kingdom
Related Organizations
Keywords

Neuropeptides, Neuromuscular Junction, 610, Inositol 1,4,5-Trisphosphate, In Vitro Techniques, Stimulation, Chemical, Cyclic AMP, Animals, Female, Cyclic GMP, Ascaris suum, Muscle Contraction

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    		 19
    popularity
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
19
Average
Average
Top 10%
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