Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor
Copyright policy )Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor
SignificanceWe have shown previously that oxytocin (Oxt), other than regulating lactation and social bonding, is a potent stimulator of bone formation by the osteoblast. Here, we present evidence that this action is exerted through the nuclear localization of the Oxt receptor (Oxtr). Our findings prompt additional studies into the contribution of nuclear Oxtr signaling in regulating lactation and social bonding.
- Mount Sinai Hospital United States
- Icahn School of Medicine at Mount Sinai United States
- Mount Sinai Health System United States
- University of Bari Aldo Moro Italy
- University of Foggia Italy
Arrestins, MAP Kinase Signaling System, Nuclear Envelope, nuclear translocation, Molecular Sequence Data, Active Transport, Cell Nucleus, Ligands, Oxytocin, Mice, Osteogenesis, Animals, Point Mutation, transcriptional regulation, G protein-coupled receptor, Amino Acid Sequence, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Mice, Knockout, Osteoblasts, Membrane Proteins, Nuclear Proteins, Amino Acid Substitution, Gene Expression Regulation
Arrestins, MAP Kinase Signaling System, Nuclear Envelope, nuclear translocation, Molecular Sequence Data, Active Transport, Cell Nucleus, Ligands, Oxytocin, Mice, Osteogenesis, Animals, Point Mutation, transcriptional regulation, G protein-coupled receptor, Amino Acid Sequence, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Mice, Knockout, Osteoblasts, Membrane Proteins, Nuclear Proteins, Amino Acid Substitution, Gene Expression Regulation
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).71 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!