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The mouse homolog of the Gibbon ape leukemia virus receptor: Genetic mapping and a possible receptor function in rodents

Name: The mouse homolog of the Gibbon ape leukemia virus receptor: Genetic mapping and a possible receptor function in rodents
Keywords: Leukemia Virus, Murine, Retroviruses, Simian, Blotting, Southern, Mice, Sequence Homology, Nucleic Acid, Animals, Chromosome Mapping, Hylobates, Receptors, Virus, Genes, env

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1991 English Publisher:Elsevier BVJournal:Virology, volume 183, pages 778-781 (issn: 0042-6822,

Authors: M. Charlene Adamson; Jonathan Silver; Christine A. Kozak;

doi: 10.1016/0042-6822(91)91010-e

pmid: 1649508

The mouse homolog of the Gibbon ape leukemia virus receptor: Genetic mapping and a possible receptor function in rodents

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Abstract

The mouse homolog of the Gibbon ape leukemia virus (GALV) receptor (Glvr-1) was mapped to mouse Chromosome 2 (Chr 2) by Southern blot analysis of somatic cell hybrids and positioned on this chromosome using an interspecies genetic cross. Mouse Chr 2 also encodes a receptor (Rec-2) for the wild mouse virus M813. To investigate whether Glvr-1 and Rec-2 could be the same gene, we sought evidence for sequence homology between the env- genes of their respective viruses. Southern blot hybridization with GALV-derived env and pol-env probes failed to detect any homology between GALV and M813, but did show that all mouse species tested carry numerous copies of GALV-related sequences. We speculate that a functional receptor for GALV-related viruses was expressed during Mus evolution.

Related Organizations

National Institute of Health
Pakistan
National Institutes of Health
United States
National Institute of Allergy and Infectious Diseases
United States

Keywords

Leukemia Virus, Murine, Retroviruses, Simian, Blotting, Southern, Mice, Sequence Homology, Nucleic Acid, Animals, Chromosome Mapping, Hylobates, Receptors, Virus, Genes, env, Polymerase Chain Reaction

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