Pleiotrophin gene expression is highly restricted and is regulated by platelet-derived growth factor
Copyright policy )Pleiotrophin gene expression is highly restricted and is regulated by platelet-derived growth factor
Pleiotrophin (PTN) is a growth and neurite extension promoting polypeptide which is highly expressed in brain and in tissues derived from mesenchyme. The PTN gene is developmentally regulated and is closely related to the MK and RI-HB genes, both of which are developmentally regulated and induced by retinoic acid. We now have screened 17 cell lines and report that expression of the PTN gene in these cells is restricted to embryo fibroblasts and intestinal smooth muscle cells. However, NIH 3T3 cells stimulated by the platelet-derived growth factor (PDGF) express a marked increase in levels of PTN mRNA whereas retinoic acid failed to increase levels of PTN mRNA in NIH 3T3 cells or in F9 embryonal carcinoma cells within 72 hours of exposure. The results suggest that expression of the PTN gene is highly restricted and that the PTN gene is a new member of the PDGF-induced cytokine family.
- University of Mary United States
- Washington University in St. Louis United States
Platelet-Derived Growth Factor, Gene Expression, 3T3 Cells, Blotting, Northern, Recombinant Proteins, Cell Line, Mice, Gene Expression Regulation, Dactinomycin, Animals, Cytokines, Humans, RNA, Cattle, RNA, Messenger, RNA, Neoplasm, Cycloheximide, Mitogens, Carrier Proteins, Cells, Cultured
Platelet-Derived Growth Factor, Gene Expression, 3T3 Cells, Blotting, Northern, Recombinant Proteins, Cell Line, Mice, Gene Expression Regulation, Dactinomycin, Animals, Cytokines, Humans, RNA, Cattle, RNA, Messenger, RNA, Neoplasm, Cycloheximide, Mitogens, Carrier Proteins, Cells, Cultured
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