ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor
Copyright policy )ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor
Genetic control elements are usually situated in local regions of chromatin that are hypersensitive to structural probes such as DNase I. We have reconstructed the chromatin structure of the hsp70 promoter using an in vitro nucleosome assembly system. Binding of the GAGA transcription factor on existing nucleosomes leads to nucleosome disruption, DNase I hypersensitivity at the TATA box and heat-shock elements, and rearrangement of adjacent nucleosomes. ATP hydrolysis facilitates this process, suggesting that an energy-dependent pathway is involved in chromatin remodelling.
- National Institutes of Health United States
- European Bioinformatics Institute United Kingdom
- European Molecular Biology Laboratory Germany
- National Cancer Institute United States
- Ludwig-Maximilians-Universität München Germany
Homeodomain Proteins, Chromatin, Chromosomes, Recombinant Proteins, Nucleosomes, DNA-Binding Proteins, Histones, Adenosine Triphosphate, Larva, Animals, Deoxyribonuclease I, Drosophila Proteins, Drosophila, Promoter Regions, Genetic, Heat-Shock Proteins, Protein Binding, Transcription Factors
Homeodomain Proteins, Chromatin, Chromosomes, Recombinant Proteins, Nucleosomes, DNA-Binding Proteins, Histones, Adenosine Triphosphate, Larva, Animals, Deoxyribonuclease I, Drosophila Proteins, Drosophila, Promoter Regions, Genetic, Heat-Shock Proteins, Protein Binding, Transcription Factors
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