The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA
Copyright policy )The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA
The innate immune system detects pathogen- and host-derived double-stranded DNA exposed to the cytosol and induces type I interferon (IFN) and other cytokines. Here, we identified interferon-inducible tripartite-motif (TRIM) 56 as a regulator of double-stranded DNA-mediated type I interferon induction. TRIM56 overexpression enhanced IFN-β promoter activation after double-stranded DNA stimulation whereas TRIM56 knockdown abrogated it. TRIM56 interacted with STING and targeted it for lysine 63-linked ubiquitination. This modification induced STING dimerization, which was a prerequisite for recruitment of the antiviral kinase TBK1 and subsequent induction of IFN-β. Taken together, these results indicate that TRIM56 is an interferon-inducible E3 ubiquitin ligase that modulates STING to confer double-stranded DNA-mediated innate immune responses.
Lysine, Ubiquitin-Protein Ligases, Immunology, Ubiquitination, Membrane Proteins, DNA, Interferon-beta, Protein Serine-Threonine Kinases, Immunity, Innate, Tripartite Motif Proteins, Infectious Diseases, HEK293 Cells, Immunology and Allergy, Humans, Promoter Regions, Genetic, HeLa Cells
Lysine, Ubiquitin-Protein Ligases, Immunology, Ubiquitination, Membrane Proteins, DNA, Interferon-beta, Protein Serine-Threonine Kinases, Immunity, Innate, Tripartite Motif Proteins, Infectious Diseases, HEK293 Cells, Immunology and Allergy, Humans, Promoter Regions, Genetic, HeLa Cells
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