Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross‐link actin
Copyright policy )Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross‐link actin
Substantial actin remodelling occurs prior to mitosis as cells alter their shape in preparation for cytokinesis. In mammalian cells, mitosis is initiated by a heterodimer of cyclin B1 and the cyclin dependent kinase 1 (Cdk1) serine/threonine kinase. In this report. we show that human cyclin B1 binds the actin cross‐linking protein Filamin‐A (FLNa). The proteins co‐immunoprecipitate and co‐localize in mitotic human cells. We find that cyclin B1/Cdk1 can phosphorylate FLNa in vitro and reduce its ability to gelate actin. We have also identified serine 1436 as one FLNa residue phosphorylated by cyclin B1/Cdk1 in vitro. Our results suggest a role for cyclin B1/Cdk1 in FLNa‐dependent actin remodelling.
Cdk1, Gelation, Filamins, Microfilament Proteins, Molecular Sequence Data, Mitosis, Cell cycle, Cyclin B, Actins, Filamin A, Contractile Proteins, Cyclin dependent kinase, Two-Hybrid System Techniques, CDC2 Protein Kinase, Protein Interaction Mapping, Serine, Humans, Amino Acid Sequence, Cyclin B1, Phosphorylation, Cytoskeleton, Actin
Cdk1, Gelation, Filamins, Microfilament Proteins, Molecular Sequence Data, Mitosis, Cell cycle, Cyclin B, Actins, Filamin A, Contractile Proteins, Cyclin dependent kinase, Two-Hybrid System Techniques, CDC2 Protein Kinase, Protein Interaction Mapping, Serine, Humans, Amino Acid Sequence, Cyclin B1, Phosphorylation, Cytoskeleton, Actin
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).39 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!