In this research, a tannic acid-modified tin oxide along with newly synthesized polyamide was used as reinforcing and anti-migration of plasticized poly(vinyl chloride) (p-PVC). Tin oxide nanoparticle was modified with tannic acid as a biobased and safe compound. The modified tin oxide was used as a reinforcement of p-PVC. Then, a fully aromatic polyamide was synthesized as the coating agent of the p-PVC. PA was used for its additional properties such as excellent mechanical strength and anti-migration properties. Characterization, morphology, mechanical properties, and blood compatibility of this nanocomposite system were done by means of attenuated total reflectance–Fourier transform infrared spectroscopy, X-ray diffraction, field-emission scanning electron microscopy, migration analysis, tensile, and hemolytic properties. In nanocomposite films with 3 mass% of tannic acid/tin oxide and coated with polyamide, an enhancement in tensile strength and elongation was observed as compared to the neat p-PVC. It was found that by incorporating the low content of nanofiller in poly(vinyl chloride) system, the migration of di(2-ethylhexyl)phthalate effectively reduced and no significant changes in mechanical properties of the poly(vinyl chloride) films were found. Furthermore, all samples did not cause any hemolytic grade of the test material which suggested that the sample had blood compatibility property.