Abstract Samples of Ti-62222-0.23wt.%Si were heat treated and aged at temperatures ranging from 1150°F to 1500°F with the view of effecting selective precipitation of α 2 precipitates and silicides (i.e. Ti x Zr 5- x Si 3 ). The effect of these intermetallic precipitates on the mechanical properties and fracture morphology was assessed via three separate microstructural conditions: Ti-62222S with α 2 precipitates, Ti-62222S with α 2 and silicide precipitates, and Ti-62222S with silicide precipitates. Both types of intermetallic precipitate appear to lower the fracture toughness, however α 2 promotes intergranular fracture while silicides lead to transgranular failure and dimpling. The combined presence of the α 2 and silicides leads to mixed mode failure. Further, since α 2 is present in the α phase and silicides precipitate out in the β phase, it appears that the effect of each of these intermetallics in Ti-62222S is additive rather than synergistic.