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Genomics
Article . 1992 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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Genomics
Article . 1992
Data sources: Europe PubMed Central
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Genomics
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Walking, cloning, and mapping with yeast artificial chromosomes: A contig encompassing D21S13 and D21S16

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1992 English Publisher:Elsevier BVJournal:Genomics, volume 12, pages 42-51 (issn: 0888-7543, Copyright policy )
Authors: R.S. Finniear; R. Butler; J. E. N. Morten; G. Slynn; Paul Elvin; John H. Riley; Alexander F. Markham; +2 Authors

doi: 10.1016/0888-7543(92)90404-g

pmid: 1733862

Walking, cloning, and mapping with yeast artificial chromosomes: A contig encompassing D21S13 and D21S16

Abstract

Chromosome 21 has often been used as a model system for the development of genome mapping and cloning strategies in humans. In this report methods for systematic chromosome walking, cloning, and mapping are exemplified in the construction of a 1.5-Mb yeast artificial chromosome (YAC) contig encompassing and extending 400 kb beyond each of the genetic loci D21S13 and D21S16. Isolation of insert-terminal sequences from YACs in this contig provides a set of closely spaced physical markers. These have been used to generate a long-range genomic restriction map.

Keywords

Genetic Markers, Base Sequence, Chromosomes, Human, Pair 21, Genome, Human, Molecular Sequence Data, Restriction Mapping, Chromosome Mapping, DNA, Polymerase Chain Reaction, Cell Line, Electrophoresis, Gel, Pulsed-Field, Chromosome Walking, Humans, Chromosomes, Fungal, Cloning, Molecular, DNA Probes, Dinucleoside Phosphates, Gene Library, Repetitive Sequences, Nucleic Acid

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    		 20
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
20
Average
Top 10%
Top 10%
gold