Involvement of MyoD and PEA3 in regulation of transcription activity of MDR1 gene
Copyright policy )Involvement of MyoD and PEA3 in regulation of transcription activity of MDR1 gene
Overexpression of multidrug resistance 1 (MDR1) in cancer remains one of the major causes for the failure of chemotherapy. In the present study, we found that MyoD and PEA3 could activate P-glycoprotein (P-gp) expression in SGC7901 cells. Knockdown of MyoD and PEA3 attenuated MDR1 expression and increased the sensitivity of multidrug resistant cancer cells to cytotoxic drugs that were transported by P-gp in SGC7901/VCR cells. MyoD or PEA3 could bind to the E-box and PEA3 sites on the MDR1 promoter and activate its transcription. The regulation of MDR1 expression by MyoD and PEA3 may provide potential ways to overcome MDR in cancer treatment.
- Fudan University China (People's Republic of)
- Wenzhou Medical University China (People's Republic of)
Transcriptional Activation, ATP Binding Cassette Transporter, Subfamily B, Antineoplastic Agents, Gene Expression Regulation, Neoplastic, Drug Resistance, Neoplasm, Stomach Neoplasms, Cell Line, Tumor, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Genes, MDR, MyoD Protein, Transcription Factors
Transcriptional Activation, ATP Binding Cassette Transporter, Subfamily B, Antineoplastic Agents, Gene Expression Regulation, Neoplastic, Drug Resistance, Neoplasm, Stomach Neoplasms, Cell Line, Tumor, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Genes, MDR, MyoD Protein, Transcription Factors
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