
Additional file 14: Figure S6. (A) Description of the goat TRGV genes. Description: The IMGT Protein display of the goat TRGV genes compared with the sheep orthologous genes. The deduced amino acid sequences of the TRGV genes were manually aligned according to IMGT unique numbering for the V-REGION [33] to maximize homology. Only functional genes, ORF and in-frame pseudogenes are shown. All sequences exhibit the typical framework regions (FR) and complementarity determining regions (CDR) and the four amino acids (indicated in bold): cysteine 23 (1st-CYS) in FR1-IMGT, tryptophan 41 (CONSERVED-TRP) in FR2-IMGT, with the exception of TRGV1 and TRGV5 subgroups, hydrophobic (here L, F and M) 89, and cysteine 104 (2nd-CYS) in FR3-IMGT. Conversely, CDR-IMGT vary in amino acid composition and length. The description of the strands and loops and of the FR-IMGT and CDR-IMGT is according to the IMGT unique numbering for V-REGION [33].
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