A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models
Copyright policy )A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models
Key PointsGlycoPEGylated FVIII (N8-GP) demonstrates the same efficacy and prolonged effect in animal models as native FVIII. Circulatory half-life of glycoPEGylated FVIII (N8-GP) is prolonged by approximately twofold in several species.
- Novo Nordisk (Denmark) Denmark
Male, Mice, Knockout, Factor VIII, Glycosylation, CHO Cells, Hemophilia A, Models, Biological, Polyethylene Glycols, Rats, Mice, Inbred C57BL, Rats, Sprague-Dawley, Disease Models, Animal, Mice, Cricetulus, Cricetinae, Animals, Humans, Female, Rabbits, Cells, Cultured
Male, Mice, Knockout, Factor VIII, Glycosylation, CHO Cells, Hemophilia A, Models, Biological, Polyethylene Glycols, Rats, Mice, Inbred C57BL, Rats, Sprague-Dawley, Disease Models, Animal, Mice, Cricetulus, Cricetinae, Animals, Humans, Female, Rabbits, Cells, Cultured
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