Descrambling DSCAM Diversity
Copyright policy )Descrambling DSCAM Diversity
Neuronal processes exhibit exquisitely complex branching patterns crucial for the formation of distinct neural circuits. In this issue of Cell, Chen et al. (2006) show that the isoform diversity of the Dscam protein in Drosophila is required to establish stereotypical axonal branching patterns, suggesting that nonrandom expression of Dscam alternative splice variants determines neural connectivity.
- Johns Hopkins University School of Medicine United States
- Johns Hopkins Medicine United States
- Howard Hughes Medical Institute United States
Central Nervous System, Biochemistry, Genetics and Molecular Biology(all), Growth Cones, Gene Expression Regulation, Developmental, Cell Differentiation, Alternative Splicing, Drosophila melanogaster, Animals, Drosophila Proteins, Protein Isoforms, Cell Adhesion Molecules
Central Nervous System, Biochemistry, Genetics and Molecular Biology(all), Growth Cones, Gene Expression Regulation, Developmental, Cell Differentiation, Alternative Splicing, Drosophila melanogaster, Animals, Drosophila Proteins, Protein Isoforms, Cell Adhesion Molecules
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