This study is a fragment of a series of immunohistochemical studies of trophoblast in case of TORCH-infections, which are scheduled at different times of gestation. This article focuses on the results of studies of the trophoblast in gestational age 5-6 weeks. The aim of the study was by means of the immunohistochemical method to determine the features of expression of MP-2 in different types of trophoblast with TORCH-infections as compared to observations without an infectious process. Abortion material of 5-6 weeks of gestation was investigated. The main group included 16 observations of TORCH-infections, and the control - 14 observations of interrupted pregnancies with no signs of infection (abortion for social reasons). Immunohistochemical method was applied on metalloproteinases-2 primary antibody and polymer system for visualization of antigen using diaminobenzidine manufactured by DAKO. Using computer microdensitometry in a specialized computer program ImageJ the optical density of color was assessed. According to the results of immunohistochemical studies using the method of microdensitometry at the gestational age of 5-6 weeks, as in TORCH-infections and infectious process, the greatest expression of metalloproteinase-2 is noted in invasive trophoblast, the lowest - in the synthitiotrophoblast of chorial villi, and intermediate rates are seen in cytotrophoblast chorial villi and cell columns. With TORCH-infections, the expression of metalloproteinase-2 is reduced in all four types of trophoblast (cytotrophoblast chorial villi; cytotrophoblast cell columns; invasive cytotrophoblast in endometrial fragments), with the exception of synthiotrophoblast of chorial villi.