Nanotechnology is a cutting-edge concept that is evolving manifolds in various fields of science and medicine and is by no means exceptional to dentistry. Nanotechnology is popularly known as the ‘science of the small’ that deals with particles of size 1-10nm. Methods like top-down or bottom-up approaches are used in manufacturing nanoparticles and nanorobots, catering to the needs of medical diagnostics and therapeutics. Nanorobotics advances medicine through miniaturization from microelectronics to nanoelectronics. Nanotechnology can be applied to all fields of dentistry such as to create nano implants, nano-drug delivery systems, nanocomposites and nano impression materials. Additionally, it helps in orthodontic tooth movement, alleviating hypersensitivity, and effective anesthesia. This paper highlights the various applications of nanotechnology in dentistry and also mentions the clinical trials performed to have a more focused approach to practicing nanodentistry. Apart from this the paper briefly explains the benefits of integrating artificial intelligence and nanotechnology for creating more personalized treatment options and also its role in Covid 19 vaccines.