<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Nicotinamide Nucleotide Transhydrogenase as a Sensor of Mitochondrial Biology

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2020 Italy Publisher:Elsevier BVJournal:Trends in Cell Biology, volume 30, pages 1-3 (issn: 0962-8924,

Authors: Nesci S.; Trombetti F.; Pagliarani A.;

doi: 10.1016/j.tcb.2019.11.001

pmid: 31753532

handle: 11585/711191

Nicotinamide Nucleotide Transhydrogenase as a Sensor of Mitochondrial Biology

- Summary
- Subjects
- Related research
  (1)
- External Databases
  (1)
- Metrics

Abstract

The enzyme nicotinamide nucleotide transhydrogenase (NNT) transfers hydride from NADH to NADP+ coupled to H+ translocation across the inner mitochondrial membrane. In a recent study, Kampjut and Sazanov reveal that the bifunctional NNT mechanism rules the NAD(P)+/NAD(P)H interconversion ratio, which in turn regulates antioxidant defense and sirtuin actions.

Country

Italy

Related Organizations

Alma Mater Studiorum University of Bologna
Italy

Keywords

Mammals, NADP Transhydrogenases, Animals, Humans, Sirtuins, antioxidant defense; mitochondria; NAD(P); +; /NAD(P)H ratio; nicotinamide nucleotide transhydrogenase; sirtuins, NAD, Oxidation-Reduction, Mitochondria

1 Research products, page 1 of 1

Uprising in Tashkent in October 1917 according to memoirs of S. V. Sazanov
2021IsAmongTopNSimilarDocuments

6qti

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	29
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%