Sex and Death: What Is the Connection?
Copyright policy )Sex and Death: What Is the Connection?
A cost of reproduction, where lifespan and fecundity are negatively correlated, is of widespread occurrence. Mutations in insulin/IGF signaling (IIS) pathways and dietary restriction (DR) can extend lifespan in model organisms but do not always reduce fecundity, suggesting that the link between lifespan and fecundity is not inevitable. Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits.
- University College London United Kingdom
- University of London United Kingdom
Biochemistry, Genetics and Molecular Biology(all), Reproduction, Longevity, Mutation, Animals, Humans, Insulin, Insulin-Like Growth Factor I, Caloric Restriction
Biochemistry, Genetics and Molecular Biology(all), Reproduction, Longevity, Mutation, Animals, Humans, Insulin, Insulin-Like Growth Factor I, Caloric Restriction
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