Silicone rubber compounded with three different types of antibacterial agents: namely; nanoAg colloids, Silver substituted Zeolite compound (SSZ) and 2-Hydroxypropyl-3-Piperazinyl-Quinoline Carboxylic Acid Methacrylate (HPQM) were prepared and changes in antibacterial performance were assessed before and after exposure to UV light at different aging times. Drop plate and halo tests were performed to study the antibacterial performance of silicone rubber compounds. The results indicated that antibacterial activity of silicone compound changed when the UV aging time was increased. The antibacterial activity of the rubber added with HPQM extremely decreased considered by the inhibition zone and %reductions of Staphylococcus aureus and Escherichia coli bacteria for any given contact times. On the other hand, the UV light did not affect the antibacterial activity of silicone rubber compounds added with nanoAg colloids and SSZ agents.