Tree‐ensemble analysis assesses presence of multifurcations in single cell data
Copyright policy )Tree‐ensemble analysis assesses presence of multifurcations in single cell data
We introduce TreeTop, an algorithm for single cell data analysis to identify and assign a branching score to branch points in biological processes which may have multi‐level branching hierarchies. We demonstrate branch point identification for processes with varying topologies, including T‐cell maturation, B‐cell differentiation and hematopoiesis. Our analyses are consistent with recent experimental studies suggesting a shallower hierarchy of differentiation events in hematopoiesis, rather than the classical multi‐level hierarchy.
Molecular Systems Biology, 15 (3)
ISSN:1744-4292
- ETH Zurich Switzerland
- University Hospital of Zurich Switzerland
- ETH-Zurich Switzerland
- Institute for Molecular Systems Biology Switzerland
Medicine (General), B-Lymphocytes, QH301-705.5, T-Lymphocytes, computational biology; proteomics; single cell RNA-seq; trajectory inference, Cell Differentiation, trajectory inference, single cell RNA‐seq, Models, Theoretical, Hematopoiesis, R5-920, computational biology, proteomics, Methods, Humans, single cell RNA-seq, Biology (General), Single-Cell Analysis, Algorithms
Medicine (General), B-Lymphocytes, QH301-705.5, T-Lymphocytes, computational biology; proteomics; single cell RNA-seq; trajectory inference, Cell Differentiation, trajectory inference, single cell RNA‐seq, Models, Theoretical, Hematopoiesis, R5-920, computational biology, proteomics, Methods, Humans, single cell RNA-seq, Biology (General), Single-Cell Analysis, Algorithms
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).3 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!