Membrane budding and scission by the ESCRT machinery: it's all in the neck
Copyright policy )Membrane budding and scission by the ESCRT machinery: it's all in the neck
The endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most unusual membrane remodelling events in cell biology. ESCRT-I and ESCRT-II direct membrane budding away from the cytosol by stabilizing bud necks without coating the buds and without being consumed in the buds. ESCRT-III cleaves the bud necks from their cytosolic faces. ESCRT-III-mediated membrane neck cleavage is crucial for many processes, including the biogenesis of multivesicular bodies, viral budding, cytokinesis and, probably, autophagy. Recent studies of ultrastructures induced by ESCRT-III overexpression in cells and the in vitro reconstitution of the budding and scission reactions have led to breakthroughs in understanding these remarkable membrane reactions.
- Washington State University United States
- National Institutes of Health United States
- National Institute of Health Pakistan
- National Institute of Diabetes and Digestive and Kidney Diseases United States
- University of Mary United States
Models, Molecular, Endosomal Sorting Complexes Required for Transport, Cell Membrane, Multivesicular Bodies, Saccharomyces cerevisiae, Models, Biological, Cytosol, Autophagy, Animals, Humans, Virus Release, Cytokinesis
Models, Molecular, Endosomal Sorting Complexes Required for Transport, Cell Membrane, Multivesicular Bodies, Saccharomyces cerevisiae, Models, Biological, Cytosol, Autophagy, Animals, Humans, Virus Release, Cytokinesis
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