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Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

descriptionPublicationkeyboard_double_arrow_right Article 07 Apr 2015 Denmark, United Kingdom English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Signaling, volume 8 (issn: 1945-0877, eissn: 1937-9145,

Authors: Anna Y. Dai; Aldis Krizus; Marina Olhovsky; Ryan Williams; Karen Colwill; Rune Linding; Rune Linding; +18 Authors

doi: 10.1126/scisignal.2005700

pmid: 25852190

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

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Abstract

Analysis of kinase signaling involved in TRAIL-induced cell death highlights potential targets for combination cancer therapy.

Countries

Denmark, United Kingdom

Related Organizations

Mount Sinai Hospital
Canada
University of Copenhagen
Denmark
Lunenfeld-Tanenbaum Research Institute
Canada
University of Toronto
Canada
Institute of Cancer Research
United Kingdom

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Keywords

Intracellular Signaling Peptides and Proteins, Apoptosis, Nerve Tissue Proteins, Adenocarcinoma, Protein Serine-Threonine Kinases, ResearchInstitutes_Networks_Beacons/mcrc; name=Manchester Cancer Research Centre, Neoplasm Proteins, TNF-Related Apoptosis-Inducing Ligand, HEK293 Cells, Cell Line, Tumor, Colonic Neoplasms, Humans, Signal Transduction

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