The Coalescent and Infinite-Site Model of a Small Multigene Family
Copyright policy )The Coalescent and Infinite-Site Model of a Small Multigene Family
Abstract The infinite-site model of a small multigene family with two duplicated genes is studied. The expectations of the amounts of nucleotide variation within and between two genes and linkage disequilibrium are obtained, and a coalescent-based method for simulating patterns of polymorphism in a small multigene family is developed. The pattern of DNA variation is much more complicated than that in a single-copy gene, which can be simulated by the standard coalescent. Using the coalescent simulation of duplicated genes, the applicability of statistical tests of neutrality to multigene families is considered.
- University of California System United States
- The University of Texas Health Science Center at Houston United States
- The University of Texas System United States
Polymorphism, Genetic, Models, Genetic, Data Interpretation, Statistical, Multigene Family, Linkage Disequilibrium
Polymorphism, Genetic, Models, Genetic, Data Interpretation, Statistical, Multigene Family, Linkage Disequilibrium
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