Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family
Copyright policy )Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family
The receptors for the I1-3/IL-5/GM-CSF cytokine family are composed of a heterodimeric complex of a cytokine-specific alpha chain and a common beta chain (betac). Binding of IL-3/IL-5/GM-CSF to their respective receptors rapidly induces activation of multiple intracellular signalling pathways, including the Ras-Raf-ERK, the JAK/STAT, the phosphatidylinositol 3-kinase PKB, and the JNK/SAPK and p38 signalling pathways. This review focuses on recent advancements in understanding how these different signalling pathways are activated by IL-3/IL-5/GM-CSF receptors, and how the individual pathways contribute to the pleiotropic effects of IL-3/IL-5/GM-CSF on their target cells, including proliferation, differentiation, survival, and effector functions.
- Utrecht University Netherlands
- University Medical Center Utrecht Netherlands
- University Museum Utrecht Netherlands
Cell Survival, Apoptosis, Kinases, Signal transduction, Geneeskunde, Phosphatidylinositol 3-Kinases, STAT5 Transcription Factor, Animals, Humans, IL-3/IL-5/GM-CSF, Granulocyte-Macrophage Colony-Stimulating Factor, Cell Differentiation, Milk Proteins, JAK/STAT, Receptors, Interleukin-3, Hematopoiesis, DNA-Binding Proteins, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Calcium-Calmodulin-Dependent Protein Kinases, Trans-Activators, Interleukin-3, Interleukin-5, Cell Division, Signal Transduction
Cell Survival, Apoptosis, Kinases, Signal transduction, Geneeskunde, Phosphatidylinositol 3-Kinases, STAT5 Transcription Factor, Animals, Humans, IL-3/IL-5/GM-CSF, Granulocyte-Macrophage Colony-Stimulating Factor, Cell Differentiation, Milk Proteins, JAK/STAT, Receptors, Interleukin-3, Hematopoiesis, DNA-Binding Proteins, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Calcium-Calmodulin-Dependent Protein Kinases, Trans-Activators, Interleukin-3, Interleukin-5, Cell Division, Signal Transduction
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