p21, p53, TP53BP1 and p73 polymorphisms and the risk of gastric cardia adenocarcinoma in a Chinese population
Copyright policy )p21, p53, TP53BP1 and p73 polymorphisms and the risk of gastric cardia adenocarcinoma in a Chinese population
Gastric cardia adenocarcinoma (GCA) is one of the most common malignant tumors and among the leading causes of cancer-related death. Genetic factors might play an important role in GCA carcinogenesis. Here, we performed a hospital-based case-control study to evaluate the effect of functional p21, p53, TP53BP1 and p73 single nucleotide polymorphisms (SNPs) on the risk of GCA. The study included 330 GCA cases and 608 controls. Genotypes were determined using the ligation detection reaction (LDR) method. The p21 rs1059234 TT, p21 rs3176352 GC/CC, p21 rs762623 GA and TP53BP1 rs560191 CC genotypes were associated with the risk of GCA, and a genotype combination effect was observed. After Bonferroni correction, the association remained significant for TP53BP1 rs560191 G > C, whereas the remaining four SNPs showed no association between the polymorphisms and GCA risk in all comparison models. Further large replication studies are needed to confirm the present findings.
- Nanjing University China (People's Republic of)
- Soochow University China (People's Republic of)
- Nanjing General Hospital of Nanjing Military Command China (People's Republic of)
- Nanjing University China (People's Republic of)
- The First People's Hospital of Changzhou China (People's Republic of)
Cyclin-Dependent Kinase Inhibitor p21, Male, China, Genotype, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, Cardia, Adenocarcinoma, Middle Aged, Polymorphism, Single Nucleotide, DNA-Binding Proteins, Logistic Models, Asian People, Gene Frequency, Risk Factors, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Aged
Cyclin-Dependent Kinase Inhibitor p21, Male, China, Genotype, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, Cardia, Adenocarcinoma, Middle Aged, Polymorphism, Single Nucleotide, DNA-Binding Proteins, Logistic Models, Asian People, Gene Frequency, Risk Factors, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Aged
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