From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2017 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 53, pages 4,394-4,397 (issn: 1359-7345, eissn: 1364-548X,

Copyright policy )

Authors: Ana Pou; José-Luís Abad; Yadira F. Ordóñez; Maria Garrido; Josefina Casas; Gemma Fabriàs; Antonio Delgado;

doi: 10.1039/c6cc08268h

pmid: 28379228

From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor

- Summary
- Subjects
- Related research
  (1)
- Metrics

Abstract

The configurational preference of Des1 towards a Δ6-unsaturated dihydroceramide analog unveils a potent Des1 inhibitor.

Related Organizations

University of Barcelona
Spain
Spanish National Research Council
Spain
Institute of Advanced Chemistry of Catalonia
Spain

Keywords

Fatty Acid Desaturases, Ceramides, Substrate Specificity, Kinetics, Isomerism, Cell Line, Tumor, Humans, Click Chemistry, Enzyme Assays

1 Research products, page 1 of 1

Accumulation of dihydrosphingolipids and neutral lipids is related to steatosis and fibrosis damage in human and animal models of non-alcoholic fatty liver disease
2022IsAmongTopNSimilarDocuments

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	7
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average