Prophylactic HIPEC with oxaliplatin might be of benefit in T4 and perforated colon cancer: another possible interpretation of the COLOPEC results
Copyright policy )Prophylactic HIPEC with oxaliplatin might be of benefit in T4 and perforated colon cancer: another possible interpretation of the COLOPEC results
The COLOPEC trial failed to show evidence for improved relapse-free survival (RFS) between the two study groups: 80,9% (95% CI 73.3-88.5) in the experimental group and 76.2 % (68.0-84.4) in the control group (one-sided log-rank p = 0.28). Nevertheless only 87 patients received the adjuvant HIPEC treatment in the experimental arm (n = 100). This group had a peritoneal relapse of 19 %, but only 10 % had a truly peritoneal relapse as 9 of them had stablished peritoneal carcinomatosis and 1 case was a peritoneal recurrence but did not receive adjuvant HIPEC. We conducted a per-protocol analysis comparing the 87 patients which truly received the adjuvant HIPEC to the 102 patients in the control arm and obtained an OR 0.396 (95 % CI 0.17-0.91) with a (Pearson Chi-Square p = 0.026, two-tailed Fisher exact test p = 0.032). This contradicts the COLOPEC reported conclusions and shows that adjuvant HIPEC could have an important protective role against peritoneal recurrence.
Oxaliplatin, Chemotherapy, Adjuvant, Antineoplastic Combined Chemotherapy Protocols, Colonic Neoplasms, Humans, Hyperthermia, Induced, Hyperthermic Intraperitoneal Chemotherapy, Neoplasm Recurrence, Local, Colorectal Neoplasms, Combined Modality Therapy
Oxaliplatin, Chemotherapy, Adjuvant, Antineoplastic Combined Chemotherapy Protocols, Colonic Neoplasms, Humans, Hyperthermia, Induced, Hyperthermic Intraperitoneal Chemotherapy, Neoplasm Recurrence, Local, Colorectal Neoplasms, Combined Modality Therapy
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