Evolution of genes and genomes on the Drosophila phylogeny
Copyright policy )Evolution of genes and genomes on the Drosophila phylogeny
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
- University of Chicago United States
- University of Salford United Kingdom
- North Carolina Agricultural and Technical State University United States
- New York University United States
- University of Arizona United States
melanogaster genome, 576.5, RNA, Untranslated, [SDV]Life Sciences [q-bio], Genome, Insect, 590, RNA, Untranslated/genetics, Genes, Insect, Genome, Insect/ genetics, Gene Order, Genome, Mitochondrial/genetics, Drosophila Proteins, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Phylogeny, Multidisciplinary, Genome, Reproduction, Untranslated, Genomics, Multigene Family/genetics, Mitochondrial, Reproduction/genetics, [SDV] Life Sciences [q-bio], DNA Transposable Elements/genetics, Genes, Insect/ genetics, Multigene Family, dosage compensation, Drosophila, amino-acid substitution, Sequence Analysis, Drosophila Proteins/genetics, 570, Synteny/genetics, Evolution, 612, fruit-fly, Synteny, Evolution, Molecular, 616, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Codon/genetics, Animals, adaptive protein evolution, Codon, Gene Order/genetics, molecular evolution, Immunity, Molecular, synonymous codon usage, DNA, Sequence Analysis, DNA, Immunity/genetics, Genes, 1000 General, Genome, Mitochondrial, DNA Transposable Elements, RNA, maximum-likelihood, noncoding dna, Drosophila/ classification/ genetics/immunology/metabolism, Insect, Sequence Alignment, natural-selection, ddc: ddc:616
melanogaster genome, 576.5, RNA, Untranslated, [SDV]Life Sciences [q-bio], Genome, Insect, 590, RNA, Untranslated/genetics, Genes, Insect, Genome, Insect/ genetics, Gene Order, Genome, Mitochondrial/genetics, Drosophila Proteins, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Phylogeny, Multidisciplinary, Genome, Reproduction, Untranslated, Genomics, Multigene Family/genetics, Mitochondrial, Reproduction/genetics, [SDV] Life Sciences [q-bio], DNA Transposable Elements/genetics, Genes, Insect/ genetics, Multigene Family, dosage compensation, Drosophila, amino-acid substitution, Sequence Analysis, Drosophila Proteins/genetics, 570, Synteny/genetics, Evolution, 612, fruit-fly, Synteny, Evolution, Molecular, 616, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Codon/genetics, Animals, adaptive protein evolution, Codon, Gene Order/genetics, molecular evolution, Immunity, Molecular, synonymous codon usage, DNA, Sequence Analysis, DNA, Immunity/genetics, Genes, 1000 General, Genome, Mitochondrial, DNA Transposable Elements, RNA, maximum-likelihood, noncoding dna, Drosophila/ classification/ genetics/immunology/metabolism, Insect, Sequence Alignment, natural-selection, ddc: ddc:616
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