IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains
Copyright policy )IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains
IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates. The NUMEROTATION concept of IMGT-ONTOLOGY has allowed to define a unique numbering for the variable domains (V-DOMAINs) and for the V-LIKE-DOMAINs. In this paper, this standardized characterization is extended to the constant domains (C-DOMAINs), and to the C-LIKE-DOMAINs, leading, for the first time, to their standardized description of mutations, allelic polymorphisms, two-dimensional (2D) representations and tridimensional (3D) structures. The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains, V-DOMAINs and C-DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMAINs and C-LIKE-DOMAINs of proteins other than IG and TR, in any species.
- University of Copenhagen Denmark
- University of Queensland Australia
- Centre de Génétique Moléculaire France
- University of Montpellier France
- University of Copenhagen Denmark
060102 Bioinformatics, V-set, 572, Molecular Sequence Data, Receptors, Antigen, T-Cell, Immunoglobulins, Protein Structure, Secondary, Sequence Analysis, Protein, Terminology as Topic, Immunoglobulin, Humans, Amino Acid Sequence, C-set, Internet, Sequence Analysis, DNA, IMGT, Protein Structure, Tertiary, Immunoglobulin superfamily, 1107 Immunology, Colliers de Perles, Constant domain, T cell receptor
060102 Bioinformatics, V-set, 572, Molecular Sequence Data, Receptors, Antigen, T-Cell, Immunoglobulins, Protein Structure, Secondary, Sequence Analysis, Protein, Terminology as Topic, Immunoglobulin, Humans, Amino Acid Sequence, C-set, Internet, Sequence Analysis, DNA, IMGT, Protein Structure, Tertiary, Immunoglobulin superfamily, 1107 Immunology, Colliers de Perles, Constant domain, T cell receptor
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