Unusual Case of Resistance to Amphotericin B in Visceral Leishmaniasis in a Region in India Where Leishmaniasis Is Not Endemic
Copyright policy )Unusual Case of Resistance to Amphotericin B in Visceral Leishmaniasis in a Region in India Where Leishmaniasis Is Not Endemic
ABSTRACT The case of a patient with visceral leishmaniasis showing inadequate response to amphotericin B from a region where leishmaniasis is not endemic is reported, with the Leishmania donovani isolate showing increased tolerance to amphotericin B in vivo . Four single nucleotide polymorphisms (SNPs) detected in the cysteine proteinase B gene resulted in changes to the deduced amino acid sequence: valine→alanine and arginine→leucine. Overexpression and underexpression of proteins were observed in the 65- to 80-kDa range and at 20 kDa, respectively.
Male, Gene Expression Profiling, Molecular Sequence Data, Antiprotozoal Agents, Drug Resistance, Mutation, Missense, India, Sequence Analysis, DNA, Polymorphism, Single Nucleotide, Molecular Weight, Cysteine Proteases, Amphotericin B, Humans, Leishmaniasis, Visceral, Aged, Leishmania donovani
Male, Gene Expression Profiling, Molecular Sequence Data, Antiprotozoal Agents, Drug Resistance, Mutation, Missense, India, Sequence Analysis, DNA, Polymorphism, Single Nucleotide, Molecular Weight, Cysteine Proteases, Amphotericin B, Humans, Leishmaniasis, Visceral, Aged, Leishmania donovani
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