Pleiotropic Deficiency in Nitrogen-Uptake Systems and Derepression of Nitrogen-Catabolic Enzymes in npr-1 Mutants of Saccharomyces cerevisiae
Copyright policy )Pleiotropic Deficiency in Nitrogen-Uptake Systems and Derepression of Nitrogen-Catabolic Enzymes in npr-1 Mutants of Saccharomyces cerevisiae
The npr-1 mutation has two types of effects in Saccharomyces cerevisiae. On one hand, several nitrogen-catabolic enzymes are derepressed in the presence of ammonia, glutamine, or asparagine, which provoke their repression in a wild-type strain. On the other hand, the activity of several ammonia-sensitive permeases is decreased (from 50-100% depending on the permease considered) in npr-1 cells, independently of the nitrogen source used for growth. Our results favour the idea that the primary effect of the npr-1 mutation is on the permeases, and that the derepression of the enzymes is a consequence of the reduced uptake rate of the repressing nitrogen compounds. Hence, the product of the npr-1 gene appears to be directly involved in the development of the activity of a set of permeases which transport nitrogen compounds and which are regulated by nitrogen effectors.
Saccharomyces cerevisiae Proteins, Amino Acid Transport Systems, Amino Acid Transport Systems, Acidic, Nitrogen, Saccharomyces cerevisiae -- enzymology, Glutamine, Acidic, Membrane Transport Proteins, Membrane Transport Proteins -- genetics, Saccharomyces cerevisiae, Sciences bio-médicales et agricoles, Ligases, Ammonia -- metabolism, Gene Expression Regulation, Nitrogen -- metabolism, Ammonia, Mutation, Asparagine -- metabolism, Carbon-Nitrogen Ligases, Glutamine -- metabolism, Asparagine, Ligases -- metabolism
Saccharomyces cerevisiae Proteins, Amino Acid Transport Systems, Amino Acid Transport Systems, Acidic, Nitrogen, Saccharomyces cerevisiae -- enzymology, Glutamine, Acidic, Membrane Transport Proteins, Membrane Transport Proteins -- genetics, Saccharomyces cerevisiae, Sciences bio-médicales et agricoles, Ligases, Ammonia -- metabolism, Gene Expression Regulation, Nitrogen -- metabolism, Ammonia, Mutation, Asparagine -- metabolism, Carbon-Nitrogen Ligases, Glutamine -- metabolism, Asparagine, Ligases -- metabolism
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