Intraperitoneal Administration of Muramyl Dipeptide β-Heptylglycoside to Pregnant and Non-Pregnant Female Mice Modulates Production of Th1/Th2/Th17/Tr1 Cytokines by Splenocytes Ex Vivo
Copyright policy )Intraperitoneal Administration of Muramyl Dipeptide β-Heptylglycoside to Pregnant and Non-Pregnant Female Mice Modulates Production of Th1/Th2/Th17/Tr1 Cytokines by Splenocytes Ex Vivo
Muramyl dipeptide β-heptylglycoside (C7MDP) was administered to non-pregnant CBA female mice and pregnant mice after non-abortion-prone mating (CBA×BALB/c) and mating associated with a high rate of spontaneous abortion (CBA×DBA/2). In non-pregnant females, C7MDP increased the production of IL-2, IL-4, IL-5, IL-6, IL-17, IFNγ, TNFα, and GM-CSF at constant production of IL-1α and IL-10. C7MDP increased the production of IL-10 and IL-17 and suppressed the production of IFNγ on day 8 of gestation in non-abortion-prone mouse couples and stimulated the synthesis of IL-4 and IFNγ, reduced IL-5 production, and slightly increased IL-1α secretion after abortion-prone mating. On day 14 of gestation, C7MDP elevated the yield of IL-2, IL-4, IFNγ, TNFα, and GM-CSF in CBA×BALB/c and CBA×DBA/2 couples and IL-17 in the fi rst variant of mating.
- Research Institute of Human Morphology Russian Federation
- Ministry of Health Russian Federation
- Sechenov University Russian Federation
Male, Mice, Inbred BALB C, Interleukins, Glycopeptides, Granulocyte-Macrophage Colony-Stimulating Factor, Lymphocyte Subsets, Abortion, Spontaneous, Disease Models, Animal, Interferon-gamma, Mice, Adjuvants, Immunologic, Mice, Inbred DBA, Embryo Loss, Mice, Inbred CBA, Animals, Cytokines, Female, Cells, Cultured, Crosses, Genetic, Injections, Intraperitoneal
Male, Mice, Inbred BALB C, Interleukins, Glycopeptides, Granulocyte-Macrophage Colony-Stimulating Factor, Lymphocyte Subsets, Abortion, Spontaneous, Disease Models, Animal, Interferon-gamma, Mice, Adjuvants, Immunologic, Mice, Inbred DBA, Embryo Loss, Mice, Inbred CBA, Animals, Cytokines, Female, Cells, Cultured, Crosses, Genetic, Injections, Intraperitoneal
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