Colorectal surgery is commonly performed for colorectal cancer but morbidity and mortality remain high and vary among surgical centers. Two elderly patients with Colorectal Cancer and a history of Chronic Obstructive Pulmonary Disease underwent epidural anesthesia plus general anesthesia for colectomy surgery. In addition, Bridium was used as an inhibitor of muscle relaxation to better awaken them. The aim of the study was to evaluate the postoperative outcome of elderly patients with colorectal cancer and session disease Chronic Obstructive Pulmonary Disease, when they undergo anesthesia to perform a major surgery such as colectomy. The combination of epidural and general anesthesia showed encouraging results in the postoperative outcome of these patients and Bridium's effect on winning was significant.