A review of the JR blood group system
Copyright policy )A review of the JR blood group system
Abstract The JR blood group system (ISBT 032) consists of one antigen, Jr a , which is of high prevalence in all populations. The rare Jr(a–) phenotype has been found mostly in Japanese and other Asian populations, but also in people of northern European ancestry, in Bedouin Arabs, and in one Mexican. Anti-Jr a has caused transfusion reactions and is involved in hemolytic disease of the fetus and newborn. The Jr a antigen is located on ABCG2 transporter, a multipass membrane glycoprotein (also known as the breast cancer resistance protein, BCRP), which is encoded by the ABCG2 gene on chromosome 4q22.1. The Jr(a–) phenotype mostly results from recessive inheritance of ABCG2 null alleles caused by frameshift or nonsense changes. Immunohematology 2013;29:63–68.
- New York Blood Center United States
- State University of Campinas Brazil
Neoplasm Proteins, Erythroblastosis, Fetal, Isoantibodies, Blood Group Antigens, ATP Binding Cassette Transporter, Subfamily G, Member 2, Humans, ATP-Binding Cassette Transporters, Chromosomes, Human, Pair 4, Alleles
Neoplasm Proteins, Erythroblastosis, Fetal, Isoantibodies, Blood Group Antigens, ATP Binding Cassette Transporter, Subfamily G, Member 2, Humans, ATP-Binding Cassette Transporters, Chromosomes, Human, Pair 4, Alleles
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