AbstractEfficient activation of the fibrinolytic pathway occurs when plasminogen and its activators are sequestered on the cell surface. Identification of receptors responsible for localizing plasminogen to the cell surface has been elusive. Using a proteomics approach, Andronicos and colleagues have identified a novel 17-kDa transmembrane receptor, termed Plg-RKT, that binds plasminogen with high affinity and promotes its activation.1