COPD causes a large disease and cost burden to the UK population. Key to understanding how to improve health within the COPD community and budget most efficiently, is understanding current practice uniformity in resource allocation. We have combined Hospital Episode Statistics (HES) data and Quality and Outcomes Framework (QOF) Registry data to analyse the hospital resource use for COPD patients across the UK region of Wessex (April 2013 to March 2014). HES and QOF data was available for 320 Primary Care Practices and all 9 Clinical Commissioning Groups (CCGs). We compared the average inpatient spend and length of stay for a primary diagnosis of COPD per diagnosed COPD patient from the QOF registry at Practice and CCG level. Prevalence across the CCGs ranged from 1.2% to 2.0%. We found a difference in inpatient admission rates (per spell) varying from 79 to 148 spells per 1000 of the COPD population in individual practices and CCGs. This represents a 1.9 fold difference in admission rates across the CCGs and a 13-fold difference in mean in-patient spend per COPD patient when comparing the 10% of lowest-spend GP practices with the 10% of highest-spend GP practices. Length of stay varied from 5.3 to 7.7 days and did not uniformly correspond to differences in 30 day readmission rates. Assuming a higher number of COPD admissions reflects poorly controlled disease, this data suggests a range of disease control across the CCGs and individual practices, even allowing for static causes of poor COPD prognosis e.g. deprivation. This provides a basis for further analysis of potential factors contributing to the variation seen within the region.