Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential
Copyright policy )Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential
Structural analysis of the RhoGEF Trio reveals modes of its activation in patients with cancer.
- University of California System United States
- University of California, San Diego United States
- University of Michigan–Flint United States
- Purdue University West Lafayette United States
- Moores Cancer Center United States
Models, Molecular, Uveal Neoplasms, 570, Carcinogenesis, 1.1 Normal biological development and functioning, 610, Crystallography, X-Ray, Cell Line, Rare Diseases, Protein Domains, Models, Uveal Melanoma, Cell Line, Tumor, Genetics, 2.1 Biological and endogenous factors, Humans, Eye Disease and Disorders of Vision, Melanoma, Cancer, Gq-G11, Tumor, Crystallography, Binding Sites, Molecular, Biological Sciences, GTP-Binding Protein alpha Subunits, HEK293 Cells, Biochemistry and cell biology, Mutation, X-Ray, GTP-Binding Protein alpha Subunits, Gq-G11, Biochemistry and Cell Biology, Generic health relevance, Guanosine Triphosphate, rhoA GTP-Binding Protein, Rho Guanine Nucleotide Exchange Factors, Protein Binding, Signal Transduction
Models, Molecular, Uveal Neoplasms, 570, Carcinogenesis, 1.1 Normal biological development and functioning, 610, Crystallography, X-Ray, Cell Line, Rare Diseases, Protein Domains, Models, Uveal Melanoma, Cell Line, Tumor, Genetics, 2.1 Biological and endogenous factors, Humans, Eye Disease and Disorders of Vision, Melanoma, Cancer, Gq-G11, Tumor, Crystallography, Binding Sites, Molecular, Biological Sciences, GTP-Binding Protein alpha Subunits, HEK293 Cells, Biochemistry and cell biology, Mutation, X-Ray, GTP-Binding Protein alpha Subunits, Gq-G11, Biochemistry and Cell Biology, Generic health relevance, Guanosine Triphosphate, rhoA GTP-Binding Protein, Rho Guanine Nucleotide Exchange Factors, Protein Binding, Signal Transduction
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