The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes
Copyright policy )The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes
A single-nucleotide polymorphism (SNP), rs2268388, in the acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with susceptibility to type 2 diabetic nephropathy (T2DN) in Japanese and European-American populations. Whether this association also exists in Chinese patients is unclear. Attempts at replication in small Singaporean and Korean samples were not significant.Eight ACACB SNPs were genotyped in 595 subjects with type 2 diabetes mellitus born in Hong Kong or southern China, 295 with advanced T2DN and 300 with long-standing diabetes lacking nephropathy. Association analyses were focused primarily on SNP rs2268388 and secondarily on flanking SNPs and haplotypes.Adjusting for age, gender and diabetes duration, ACACB SNP rs2268388 was significantly associated with advanced T2DN (odds ratio = 2.39; recessive model; P = 0.0129).These results in the Chinese replicate the association between T2DN and rs2268388, as seen in Japanese and European Americans. The ACACB gene and attendant alterations in fatty acid oxidation may play important roles in susceptibility to T2DN. Targeting this pathway may provide novel treatment options for the prevention of diabetic nephropathy.
- University of Hong Kong (香港大學) China (People's Republic of)
- Wake Forest University United States
- Alabama Agricultural and Mechanical University United States
- University of California, San Francisco United States
- San Francisco VA Health Care System United States
Male, kidney, China, 571, Genotype, type 2 diabetes mellitus, Diabetic Nephropathies - ethnology - etiology - genetics, Polymorphism, Single Nucleotide, Japan, Diabetes Mellitus, Single Nucleotide - genetics, Humans, Diabetic Nephropathies, Genetic Predisposition to Disease, Polymorphism, Diabetes Mellitus, Type 2 - complications - ethnology - genetics, Aged, Chinese, diabetic nephropathy, Middle Aged, Acetyl-CoA Carboxylase - genetics, Polymorphism, Single Nucleotide - genetics, United States, Europe, Diabetes Mellitus, Type 2, Haplotypes, ACACB, Type 2 - complications - ethnology - genetics, Case-Control Studies, Genetic Predisposition to Disease - genetics, Female, Acetyl-CoA Carboxylase
Male, kidney, China, 571, Genotype, type 2 diabetes mellitus, Diabetic Nephropathies - ethnology - etiology - genetics, Polymorphism, Single Nucleotide, Japan, Diabetes Mellitus, Single Nucleotide - genetics, Humans, Diabetic Nephropathies, Genetic Predisposition to Disease, Polymorphism, Diabetes Mellitus, Type 2 - complications - ethnology - genetics, Aged, Chinese, diabetic nephropathy, Middle Aged, Acetyl-CoA Carboxylase - genetics, Polymorphism, Single Nucleotide - genetics, United States, Europe, Diabetes Mellitus, Type 2, Haplotypes, ACACB, Type 2 - complications - ethnology - genetics, Case-Control Studies, Genetic Predisposition to Disease - genetics, Female, Acetyl-CoA Carboxylase
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