Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.
Copyright policy )Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.
Osteogenic protein-2, OP-2, a new member of the transforming growth factor-beta (TGF-beta) superfamily, closely related to the osteogenic/bone morphogenetic proteins, was discovered in mouse embryo and human hippocampus cDNA libraries. The TGF-beta domain of OP-2 shows 74% identity to OP-1, 75% to Vgr-1, and 76% to BMP-5, hence OP-2 may also have bone inductive activity. The genomic locus of OP-2 has seven exons, like OP-1, and spans more than 27 kilobases (kb). In the C-terminal TGF-beta domain, OP-2 has a unique additional cysteine. Mouse embryos express relatively high levels of OP-2 mRNA at 8 days, two species of 3 and 5 kb. A careful study of mRNA expression of the osteogenic proteins in specific organs revealed discrete mRNA species for BMP-3, BMP-4, BMP-5, and BMP-6/Vgr-1 in lung or liver of young and adult mice. OP-1 is expressed in kidney; however, OP-2 and BMP-2 mRNAs were not detected in any organs studied, suggesting an early developmental role.
- Massachusetts Institute of Technology United States
- Whitehead Institute for Biomedical Research United States
Base Sequence, Molecular Sequence Data, Bone Morphogenetic Protein 2, Gene Expression, DNA, Exons, Embryo, Mammalian, Hippocampus, Embryonic and Fetal Development, Mice, Animals, Newborn, Oligodeoxyribonucleotides, Organ Specificity, Multigene Family, Bone Morphogenetic Proteins, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Gene Library
Base Sequence, Molecular Sequence Data, Bone Morphogenetic Protein 2, Gene Expression, DNA, Exons, Embryo, Mammalian, Hippocampus, Embryonic and Fetal Development, Mice, Animals, Newborn, Oligodeoxyribonucleotides, Organ Specificity, Multigene Family, Bone Morphogenetic Proteins, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Gene Library
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