Insulin‐like growth factor‐binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells
Copyright policy )Insulin‐like growth factor‐binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells
AbstractInsulin‐like growth factor 1 (IGF‐1) is a growth and survival factor for oligodendrocyte lineage cells and promotes myelination. We demonstrate that IGF‐binding protein 6 (IGFBP‐6) is expressed and localized to the Golgi complex in rat oligodendrocyte precursor (O2A) cells. IGFBP‐6 mRNA showed a developmentally regulated expression pattern, displaying a transient decrease during early development, and enhanced levels upon cell maturation. IGFBP‐6 mRNA expression could be reduced by addition of basic fibroblast growth factor and progesterone while estrogen increased IGFBP‐6 mRNA. IGF‐1, platelet‐derived growth factor, and insulin had no effect. When added exogenously, IGFBP‐6 reduced O2A cell survival in the absence of IGF‐1 and inhibited IGF‐1‐stimulated survival in a partially IGF‐1‐dependent and partially IGF‐1‐independent fashion. In addition, IGFBP‐6 reduced the IGF‐stimulated expression of two myelin proteins, CNPase and MAG. Taken together, the data show that IGFBP‐6 is a new negative effector of oligodendrocyte survival and differentiation. © 2003 Wiley‐Liss, Inc.
- Vrije Universiteit Brussel Belgium
- University of Groningen Netherlands
FACTOR-BINDING-PROTEIN, Cell Survival, mRNA, Cell Differentation/physiology, Insulin-Like-Growth-Factor-Binding Protein, SELECTIVE AFFINITY, myelin proteins, survival, Myelin-Assoc. Glycoprotein/antagonists, CEREBROSPINAL-FLUID, 2',3'-Cyclic-Nucleotide Phosphodiesterases/antagon, GROWTH-FACTOR-I, HUMAN NEUROBLASTOMA-CELLS, Animals, O2A cells, RNA, Messenger, Rats, Wistar, Cell survival/physiology, Cells, Cultured, GENE-EXPRESSION, des(1-3)-IGF-1, Cultured, 6/biosynthesis/genetics/physiology, Stem Cells, CENTRAL-NERVOUS-SYSTEM, Gene Expression Regulation, Developmental, Developmental/physiology, Cell Differentiation, Growth Inhibitors, IGF-I, Rats, Myelin-Associated Glycoprotein, Oligodendroglia, Gene Expression Regulation, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, FACTOR (IGF)-BINDING PROTEINS, inhibitors/biosynthesis, CELLS, 2',3'-Cyclic-Nucleotide Phosphodiesterases, Insulin-Like Growth Factor Binding Protein 6, Growth Inhibitors/biosynthesis/genetics/physiology
FACTOR-BINDING-PROTEIN, Cell Survival, mRNA, Cell Differentation/physiology, Insulin-Like-Growth-Factor-Binding Protein, SELECTIVE AFFINITY, myelin proteins, survival, Myelin-Assoc. Glycoprotein/antagonists, CEREBROSPINAL-FLUID, 2',3'-Cyclic-Nucleotide Phosphodiesterases/antagon, GROWTH-FACTOR-I, HUMAN NEUROBLASTOMA-CELLS, Animals, O2A cells, RNA, Messenger, Rats, Wistar, Cell survival/physiology, Cells, Cultured, GENE-EXPRESSION, des(1-3)-IGF-1, Cultured, 6/biosynthesis/genetics/physiology, Stem Cells, CENTRAL-NERVOUS-SYSTEM, Gene Expression Regulation, Developmental, Developmental/physiology, Cell Differentiation, Growth Inhibitors, IGF-I, Rats, Myelin-Associated Glycoprotein, Oligodendroglia, Gene Expression Regulation, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, FACTOR (IGF)-BINDING PROTEINS, inhibitors/biosynthesis, CELLS, 2',3'-Cyclic-Nucleotide Phosphodiesterases, Insulin-Like Growth Factor Binding Protein 6, Growth Inhibitors/biosynthesis/genetics/physiology
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