A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast
Copyright policy )A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast
Using a yeast model of Parkinson's disease, we found that alpha-synuclein (αS) binds to lipid droplets in lipid-loaded, wild-type yeast cells but not to lipid droplets in lipid-loaded, peroxisome-deficient cells (pex3Δ). Our analysis revealed that pex3Δ cells have both fewer lipid droplets and smaller lipid droplets than wild-type cells, and that the acyl chains of the phospholipids on the surface of the lipid droplets from pex3Δ cells are on average shorter (C16) than those (C18) on the surface of lipid droplets from wild-type cells. We propose that the shift to shorter (C18→C16) acyl chains contributes to the reduced binding of αS to lipid droplets in pex3Δ cells.
- Louisiana State University Health Sciences Center Shreveport United States
- University of North Texas United States
- University of Wyoming United States
Saccharomyces cerevisiae Proteins, Surface Properties, Green Fluorescent Proteins, Membrane Proteins, Parkinson Disease, Saccharomyces cerevisiae, Lipids, Fungal Proteins, Peroxins, Peroxisomes, alpha-Synuclein, Hydrophobic and Hydrophilic Interactions, Phospholipids, Plasmids, Protein Binding
Saccharomyces cerevisiae Proteins, Surface Properties, Green Fluorescent Proteins, Membrane Proteins, Parkinson Disease, Saccharomyces cerevisiae, Lipids, Fungal Proteins, Peroxins, Peroxisomes, alpha-Synuclein, Hydrophobic and Hydrophilic Interactions, Phospholipids, Plasmids, Protein Binding
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