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Type I interferons and T helper development

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2000 English Publisher:Elsevier BVJournal:Immunology Today, volume 21, pages 484-489 (issn: 0167-5699,

Authors: J. David Farrar; Kenneth M. Murphy;

doi: 10.1016/s0167-5699(00)01710-2

pmid: 11071526

Type I interferons and T helper development

- Summary
- Subjects
- Related research
  (9)
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Abstract

Abstract Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4 + T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4 + T cells to undergo IFN-1-induced Stat4 activation and Th1 development.

Related Organizations

Washington State University
United States
University of Mary
United States
Howard Hughes Medical Institute
United States

Keywords

CD4-Positive T-Lymphocytes, Immunity, Cellular, Molecular Sequence Data, Cell Differentiation, STAT2 Transcription Factor, T-Lymphocytes, Helper-Inducer, STAT4 Transcription Factor, Th1 Cells, Immunity, Innate, DNA-Binding Proteins, Mice, Mutagenesis, Insertional, Species Specificity, Interferon Type I, Trans-Activators, Animals, Humans, Amino Acid Sequence, Sequence Alignment

9 Research products, page 1 of 1

Signal transducer and activator of transcription
2017IsRelatedTo
Stat2 protein
2017IsRelatedTo
Signal transducer and activator of transcription
2017IsRelatedTo
Signal transducer and activator of transcription
2017IsRelatedTo
Signal transducer and activator of transcription
2017IsRelatedTo
Signal transducer and activator of transcription 2
2017IsRelatedTo
Signal transducer and activator of transcription
2017IsRelatedTo
Uncharacterized protein
2017IsRelatedTo
Signal transducer and activator of transcription
2017IsRelatedTo

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	95
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%