Immunohistochemistry of COUP-TFI: an adjuvant diagnostic tool for the identification of corticotroph microadenomas
Copyright policy )Immunohistochemistry of COUP-TFI: an adjuvant diagnostic tool for the identification of corticotroph microadenomas
Cushing's disease is caused by an ACTH-producing pituitary tumor, and accounts for 10-15% of pituitary tumors. The majority of corticotroph tumors are microadenomas (90%) expression of COUP-TFI, and three adenomas (5, 11, and 18 mm) showed heterogenous (20-80%) expression of COUP-TFI. Immunohistochemistry of COUP-TFI may be a useful adjuvant diagnostic tool in distinguishing corticotroph microadenomas from nests of normal corticotroph cells in the anterior pituitary. Furthermore, this study identifies two unique corticotroph tumor populations which differ in their expression of COUP-TFI, the presence of which occurs more frequently in macroadenomas.
- Brigham and Women's Faulkner Hospital United States
- University of Virginia Health System United States
Adenoma, Diagnosis, Differential, ACTH-Secreting Pituitary Adenoma, COUP Transcription Factor I, Molecular Diagnostic Techniques, Humans, Tissue Distribution, Immunohistochemistry, Retrospective Studies
Adenoma, Diagnosis, Differential, ACTH-Secreting Pituitary Adenoma, COUP Transcription Factor I, Molecular Diagnostic Techniques, Humans, Tissue Distribution, Immunohistochemistry, Retrospective Studies
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